Oleg Mayba | 18 Jun 2012 08:11

nearest() for GRanges

Hi,

I just noticed that a piece of logic I was relying on with GRanges before
does not seem to work anymore.  Namely, I expect the behavior of nearest()
with a single GRanges object as an argument to be the same as that of
IRanges (example below), but it's not anymore.  I expect nearest(GR1) NOT
to behave trivially but to return the closest range OTHER than the range
itself.  I could swear that was the case before, but isn't any longer:

> z=IRanges(start=c(1,5,10), end=c(2,7,12))
> z
IRanges of length 3
    start end width
[1]     1   2     2
[2]     5   7     3
[3]    10  12     3
> nearest(z)
[1] 2 1 2
>
> z=GRanges(seqnames=rep('chr1',3),ranges=IRanges(start=c(1,5,10),
end=c(2,7,12)))
> z
GRanges with 3 ranges and 0 elementMetadata cols:
      seqnames    ranges strand
         <Rle> <IRanges>  <Rle>
  [1]     chr1  [ 1,  2]      *
  [2]     chr1  [ 5,  7]      *
  [3]     chr1  [10, 12]      *
  ---
  seqlengths:
   chr1
     NA
> nearest(z)
[1] 1 2 3
>
> sessionInfo()
R version 2.15.0 (2012-03-30)
Platform: x86_64-unknown-linux-gnu (64-bit)

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C
 [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8
 [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8
 [7] LC_PAPER=C                 LC_NAME=C
 [9] LC_ADDRESS=C               LC_TELEPHONE=C
[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C

attached base packages:
[1] datasets  utils     grDevices graphics  stats     methods   base

other attached packages:
[1] GenomicRanges_1.8.6 IRanges_1.14.3      BiocGenerics_0.2.0

loaded via a namespace (and not attached):
[1] stats4_2.15.0
>

I want the IRanges behavior and not what seems currently to be the GRanges
behavior, since I have some code that depends on it. Is there a quick way
to make nearest() do that for me again?

Thanks!

Oleg.

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