Davide Cittaro | 5 Feb 07:23 2013
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Re: statistical test for time course data


On Feb 5, 2013, at 4:02 AM, Gordon K Smyth <smyth@...> wrote:

> Dear Rich,
> 
> I have added a time course example using splines to the limma User's 
> Guide, see page 48:
> 
> http://bioconductor.org/packages/2.12/bioc/vignettes/limma/inst/doc/usersguide.pdf
> 

Does this work also for RNA-seq data?

d

> Best wishes
> Gordon
> 
> ------------------ original message ------------------
> [BioC] statistical test for time course data
> Richard Friedman friedman at cancercenter.columbia.edu
> Sun Feb 3 20:18:03 CET 2013
> 
> Dear Gordon,
> 
> 	Thank you very much for the clarification. Now that I think of it, 
> the one-against all is straightforward. However, If there are any worked 
> examples you could point me towards for polynomial and spline modeling of 
> the time series I would greatly appreciate it. I am especially interested 
> in testing the hypothesis that the temporal behavior of 2 treatments are 
> different.
> 
> Best wishes,
> Rich
> 
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